William M. Armstead

Professor
Department of Anesthesiology and Critical Care Medicine 
Pennsylvania State University
United States of America

Professor Anesthesiology
Biography

Dr. William M. Armstead works as Professor of Clinical Anesthesiology and Critical Care at The University of Pennsylvania Health System. He is also working as a member for Institute of Neurological Sciences, University of Pennsylvania, Cardiovascular Institute, University of Pennsylvania. He received his B.A. (Biochemistry) from University of Pennsylvania, 1979., and Ph.D. (Pharmacology) from Tulane University, 1985. His research interests include: Dr. Armstead's research focuses on characterizing mechanisms important in the control of cerebral hemodynamics under physiologic and pathologic conditions such as traumatic brain injury (TBI), stroke, and cerebral hypoxia/ischemia, particularly in the newborn. Current projects focus on interactions between the NMDA receptor and plasminogen activators after TBI, optimizing the efficacy/toxicity ratio of tPA, the only FDA approved treatment for stroke and translational research concerning the roles of sex and age in outcome after pediatric TBI.

Research Intrest

Control of cerebral hemodynamics during physiologic and pathologic conditions such as traumatic brain injury, stroke, and cerebral ischemia/reperfusion. 

List of Publications
Armstead WM, Riley J, Vavilala MS, (2017) K channel impairment determines sex and age differences in epinephrine-mediated outcomes after brain injury. J of Neuroscience Research 95: 1917-1926
Curvello V, Hekierski H, Riley J, Vavilala M, Armstead WM, (2017) Sex and age differences in phenylephrine mechanisms and outcomes after piglet brain injury. Ped Res 82: 108-113
Curvello V, Hekierski H, Pastor P, Vavilala M, Armstead WM, (2017) Dopamine protects cerebral autoregulation and prevents hippocampal necrosis after traumatic brain injury via block of ERK MAPK in juvenile pigs. Brain Research 1670: 118-124