Seema Singh

Associate Professor
Oncologic Sciences
Mitchell Cancer Institute
United States of America

Professor Oncology
Biography

Dr. Seema Singh joined MCI in 2009 as Instructor of Oncologic Sciences. She quickly established a robust, independent laboratory program and was promoted to Assistant Professor in 2012 and then to Associate Professor in 2016. Her primary areas of interest include the role of inflammatory signaling in cancer progression, angiogenesis and metastasis, cancer stem cells and cancer health disparities. After obtaining a Ph.D. in India in 2001, she received postdoctoral training at University of Nebraska Medical Center in the area of tumor microenvironment, and breast and melanoma pathobiology. She is currently focused on the identification of novel targets in melanoma, and investigating the role of inflammatory and DNA damage pathways in the etiology and progression of non-melanoma skin cancer. Her team has discovered a novel role of silver nanoparticles (AgNPs) in the protection of keratinocytes from UV radiation-induced DNA damage and apoptosis. She is also exploring the role of differential tumor microenvironment in breast cancer racial disparity. Her research programs have been funded through NIH/NCI, and she has also served on peer review committees to evaluate grant applications.

Research Intrest

Inflammation and Cancer, Tumor Microenvironment, Tumor Progression and Metastasis, Molecular bases of cancer health disparities, Nanobiotechnology

List of Publications
Cheng G, Varanasi P, Li C, Liu H, Melnichenko YB, Simmons BA, Kent MS, Singh S. Transition of cellulose crystalline structure and surface morphology of biomass as a function of ionic liquid pretreatment and its relation to enzymatic hydrolysis. Biomacromolecules. 2011 Feb 25;12(4):933-41.
Singh S, Simmons BA, Vogel KP. Visualization of biomass solubilization and cellulose regeneration during ionic liquid pretreatment of switchgrass. Biotechnology and Bioengineering. 2009 Sep 1;104(1):68-75.
Singh S, Shi T, Duffin R, Albrecht C, van Berlo D, Höhr D, Fubini B, Martra G, Fenoglio I, Borm PJ, Schins RP. Endocytosis, oxidative stress and IL-8 expression in human lung epithelial cells upon treatment with fine and ultrafine TiO 2: role of the specific surface area and of surface methylation of the particles. Toxicology and applied pharmacology. 2007 Jul 15;222(2):141-51.
Li C, Knierim B, Manisseri C, Arora R, Scheller HV, Auer M, Vogel KP, Simmons BA, Singh S. Comparison of dilute acid and ionic liquid pretreatment of switchgrass: biomass recalcitrance, delignification and enzymatic saccharification. Bioresource technology. 2010 Jul 31;101(13):4900-6.