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Experts in Genetics
Sanjay Gupta Aimée M. Dudley David Buchanan Drena Dobbs Karin S Dorman Dr. Xun Gu Thomas Peterson IRFAN AHMAD ANSARI John Golin Jannice Friedman Vimla Aggarwal Andrea Rinaldi Carmen Argmann Eleanor Maine Albertini Alessandra Judith Greenberg Mark Clark John F. Hayes Ashok Kumar Roger I. Cue View MorePaul W Burridge
Assistant Professor
Center for Genetic Medicine
Northwestern University
United States of America
We study the application of patient-specific human induced pluripotent stem cells in studying the role of the genome in influencing drug responses, a field known as pharmacogenomics or personalized medicine. Our major effort has been focused on patient-specific responses to chemotherapy agents. We ask the question: what is the genetic reason why some patients have minimal side effects of their cancer treatments, whilst others encounter highly detrimental side effects? These side effects can include cardiomyopathy (heart failure or arrhythmias), peripheral neuropathy, or hepatotoxicity (liver failure). It is our aim to add to risk-based screening by functionally validating genetic changes that predispose a patient to a specific drug response. We use a combination of next-generation sequencing, automation and robotics, high-throughput drug screening, high-content imaging, tissue engineering, and electrophysiological testing to better understand the mechanisms of drug response and action
Adverse Drug Reactions, Breast Cancer, Cardiology Drug Discovery Bioengineering Stem Cells Regenerative Medicine Bioinformatics