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Michael J Avram

Associate Professor of Anesthesiology
Northwestern University Feinberg School of Medicine
United States of America

Professor Anesthesiology
Biography

Dr. Avram’s research interests include pharmacokinetics (PKs) and pharmacodynamics (PDs) of hypnotics, sedatives, opioids, analgesics, non-depolarizing neuromuscular blockers, chemotherapeutics, etc. His major research focus has been the development and evaluation of detailed PK models of rapidly acting intravanously administered drugs from the moment of injection to serve as the basis for understanding the PK basis of interindividual variability in response to these agents, which often have low clinical margins of safety.

Research Intrest

clinical pharmacology, pharmacokinetics

List of Publications
Rationale and design for an investigation to optimize selective serotonin reuptake inhibitor treatment for pregnant women with depression Avram MJ, Stika CS, Rasmussen-Torvik LJ, Ciolino JD, Pinheiro E, George AL, Wisner KL Clinical Pharmacology and Therapeutics. 2016 Jul; 100(1): 31-33. doi:http://dx.doi.org/10.1002/cpt.375. PMID: 27037844 ISSN: 0009-9236
A microfluidic culture model of the human reproductive tract and 28-day menstrual cycle Xiao S, Coppeta JR, Rogers HB, Isenberg BC, Zhu J, Olalekan SA, McKinnon KE, Dokic D, Rashedi AS, Haisenleder DJ, Malpani SS, Arnold-Murray CA, Chen K, Jiang M, Bai L, Nguyen CT, Zhang J, Laronda MM, Hope TJ, Maniar KP, Pavone ME, Avram MJ, Sefton EC, Getsios S, Burdette JE, Kim JJ, Borenstein JT, Woodruff TK Nature Communications. 2017 Mar 28; 8: doi:http://dx.doi.org/10.1038/ncomms14584. PMID: 28350383 PMCID: 28350383 ISSN: 2041-1723
Clinical Effectiveness and Safety of Intraoperative Methadone in Patients Undergoing Posterior Spinal Fusion Surgery: A Randomized, Double-blinded, Controlled Trial Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Shear TD, Deshur MA, Vender JS, Benson J, Newmark RL Anesthesiology. 2017 May; 126(5): 822-833. doi:http://dx.doi.org/10.1097/ALN.0000000000001609. PMID: 28418966 ISSN: 0003-3022
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