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Lee Nadler

Professor
Departmaent of Clinical and Translational Research
Harvard Medical School
United States of America

Professor Oncology
Biography

Lee M. Nadler is the Virginia and D.K. Ludwig Professor for Cancer Research and Teaching, the Dean for Clinical and Translational Research, and the Director of Harvard Catalyst at Harvard Medical School.  He is the Senior Vice President for Academic Integration and the Pan Mass Challenge Senior Investigator at the Dana-Farber Cancer Institute. Dr. Nadler’s laboratory discovered the human B-cell specific molecules CD19, CD20, CD21 and CD22 and the costimulatory molecules B7-1 (CD80) and B7-2 (CD86). His translational experiments established our understanding of human B-cell differentiation and led to the worldwide immunologic classification of human B-cell leukemias and lymphomas. Similarly, he was the first to administer a monoclonal antibody to a human and to use monoclonal antibodies to improve the outcome of human stem cell transplantation. His discovery and characterization of the B1 molecule (CD20) led to the development of Rituxan that has significantly improved the survival of patients with lymphomas and other B-cell diseases throughout the world.

Research Intrest

 Oncology Hematologic Malignancies lymphomas B-cell leukemias B-cell diseases

List of Publications
Ansén S, Butler MO, Berezovskaya A, Murray AP, Stevenson K, Nadler LM, Hirano N. Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21. Clin Cancer Res. 2008 Oct 01; 14(19):6125-36. PMID: 18829491; PMCID: PMC2570356.
Kondo E, Maecker B, Weihrauch MR, Wickenhauser C, Zeng W, Nadler LM, Schultze JL, von Bergwelt-Baildon MS. Cyclin D1-specific cytotoxic T lymphocytes are present in the repertoire of cancer patients: implications for cancer immunotherapy. Clin Cancer Res. 2008 Oct 15; 14(20):6574-9. PMID: 18927298.
Davies JK, Nadler LM, Guinan EC. Expansion of allospecific regulatory T cells after anergized, mismatched bone marrow transplantation. Sci Transl Med. 2009 Oct 07; 1(1):1ra3. PMID: 20368155; PMCID: PMC3225049.
Davies JK, Singh H, Huls H, Yuk D, Lee DA, Kebriaei P, Champlin RE, Nadler LM, Guinan EC, Cooper LJ. Combining CD19 redirection and alloanergization to generate tumor-specific human T cells for allogeneic cell therapy of B-cell malignancies. Cancer Res. 2010 May 15; 70(10):3915-24. PMID: 20424114; PMCID: PMC2873153.
Butler MO, Ansén S, Tanaka M, Imataki O, Berezovskaya A, Mooney MM, Metzler G, Milstein MI, Nadler LM, Hirano N. A panel of human cell-based artificial APC enables the expansion of long-lived antigen-specific CD4+ T cells restricted by prevalent HLA-DR alleles. Int Immunol. 2010 Nov; 22(11):863-73. PMID: 21059769; PMCID: PMC2994545.
Batista A, Barata JT, Raderschall E, Sallan SE, Carlesso N, Nadler LM, Cardoso AA. Targeting of active mTOR inhibits primary leukemia T cells and synergizes with cytotoxic drugs and signaling inhibitors. Exp Hematol. 2011 Apr; 39(4):457-472.e3. PMID: 21277936.
Furman RR, Grossbard ML, Johnson JL, Pecora AL, Cassileth PA, Jung SH, Peterson BA, Nadler LM, Freedman A, Bayer RL, Bartlett NL, Hurd DD, Cheson BD. A phase III study of anti-B4-blocked ricin as adjuvant therapy post-autologous bone marrow transplant: CALGB 9254. Leuk Lymphoma. 2011 Apr; 52(4):587-96. PMID: 21275630; PMCID: PMC3682835.
Davies JK, Barbon CM, Voskertchian AR, Nadler LM, Guinan EC. Induction of alloantigen-specific anergy in human peripheral blood mononuclear cells by alloantigen stimulation with co-stimulatory signal blockade. J Vis Exp. 2011 Mar 14; (49). PMID: 21445041; PMCID: PMC3197423.
Butler MO, Friedlander P, Milstein MI, Mooney MM, Metzler G, Murray AP, Tanaka M, Berezovskaya A, Imataki O, Drury L, Brennan L, Flavin M, Neuberg D, Stevenson K, Lawrence D, Hodi FS, Velazquez EF, Jaklitsch MT, Russell SE, Mihm M, Nadler LM, Hirano N. Establishment of antitumor memory in humans using in vitro-educated CD8+ T cells. Sci Transl Med. 2011 Apr 27; 3(80):80ra34. PMID: 21525398; PMCID: PMC3861895.
Maia S, Pelletier M, Ding J, Hsu YM, Sallan SE, Rao SP, Nadler LM, Cardoso AA. Aberrant expression of functional BAFF-system receptors by malignant B-cell precursors impacts leukemia cell survival. PLoS One. 2011; 6(6):e20787. PMID: 21687682; PMCID: PMC3110793.
Tanaka M, Butler MO, Ansén S, Imataki O, Berezovskaya A, Nadler LM, Hirano N. Induction of HLA-DP4-restricted anti-survivin Th1 and Th2 responses using an artificial antigen-presenting cell. Clin Cancer Res. 2011 Aug 15; 17(16):5392-401. PMID: 21705450; PMCID: PMC3156899.
Imataki O, Ansén S, Tanaka M, Butler MO, Berezovskaya A, Milstein MI, Kuzushima K, Nadler LM, Hirano N. IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells. J Immunol. 2012 Feb 15; 188(4):1609-19. PMID: 22238455; PMCID: PMC3273545.
Butler MO, Imataki O, Yamashita Y, Tanaka M, Ansén S, Berezovskaya A, Metzler G, Milstein MI, Mooney MM, Murray AP, Mano H, Nadler LM, Hirano N. Ex vivo expansion of human CD8+ T cells using autologous CD4+ T cell help. PLoS One. 2012; 7(1):e30229. PMID: 22279573; PMCID: PMC3257268.
Davies JK, Barbon CM, Voskertchian A, Nadler LM, Guinan EC. Ex vivo alloanergization with belatacept: a strategy to selectively modulate alloresponses after transplantation. Cell Transplant. 2012; 21(9):2047-61. PMID: 22507909.
Barbon CM, Davies JK, Voskertchian A, Kelner RH, Brennan LL, Nadler LM, Guinan EC. Alloanergization of human T cells results in expansion of alloantigen-specific CD8(+) CD28(-) suppressor cells. Am J Transplant. 2014 Feb; 14(2):305-18. PMID: 24410845.
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