Biography

He has done his Ph.D., 2002, University of Illinois, Urbana-Champaign, M.S., 1999, University of Illinois, Urbana-Champaign, B.S., 1997, North Dakota State University, Fargo.

Research Intrest

Our laboratory uses genomic biology to study nutrition-related problems in the areas of 'obesity' and 'intestinal health'. Both comparative and applied nutrition research projects are performed in our laboratory, including those studying human subjects, companion animals, and rodent models. A primary aim of our laboratory is to study the effects of diet and age on gastrointestinal microbiota abundance and activity. DNA-based techniques [e.g., quantitative polymerase chain reaction (qPCR); next-generation sequencing] are used in the lab. Current projects are designed to evaluate the effects of dietary fibers and prebiotics, dietary lipids, and protein: carbohydrate ratio on gastrointestinal microbial populations. Key associations between intestinal microbiota, host physiology, and disease are also being studied. Another primary area of research pertains to energy homeostasis and obesity. Molecular techniques (e.g., qRT-PCR; Fluidigm; RNAseq) are used to identify mechanisms and/or metabolic pathways affected in key metabolic tissues. Adipose tissue and skeletal muscle play important roles in energy homeostasis and glucose and lipid metabolism and are the focus of several ongoing projects.

List of Publications
Deng, P., J. C. Jones, and K. S. Swanson. 2014. Effects of dietary macronutrient composition on the fasted plasma metabolome of healthy adult cats. Metabolomics 10:638-650.
Deusch, O., C. O’Flynn, A. Colyer, P. Morris, D. Allaway, P. G. Jones, and K. S. Swanson. 2014. Deep Illumina-based shotgun sequencing reveals dietary effects on the structure and function of the fecal microbiome of growing kittens. PLoS ONE 9:e101021.
Holscher, H. D., L. L. Bauer, V. Gourineni, C. L. Pelkman, G. C. Fahey, Jr., and K. S. Swanson. 2015. Agave inulin supplementation affects the fecal microbiota of healthy adults participating in a randomized, double-blind, placebo-controlled crossover trial. J. Nutr. 145:2025-2032.
Holscher, H. D., J. G. Caporaso, S. Hooda, J. M. Brulc, G. C. Fahey, Jr., and K. S. Swanson. 2015. Fiber supplementation influences phylogenetic structure and functional capacity of the human intestinal microbiome: Follow-up of a randomized controlled trial. Am. J. Clin. Nutr. 101:55-64.
Liu, T.-W., K. D. Cephas, H. D. Holscher, K. R. Kerr, H. F. Mangian, K. A. Tappenden, and K. S. Swanson. 2016. Nondigestible fructans alter gastrointestinal barrier function, gene expression, histomorphology, and the microbiota profiles of diet-induced obese C57BL/6J mice. J. Nutr. 146:949-956.
Ma, L., T.-W. Liu, M. A. Wallig, I. T. Dobrucki, L. W. Dobrucki, E. R. Nelson, K. S. Swanson, and A. M. Smith. 2016. Efficient targeting of adipose tissue macrophages in obesity with polysaccharide nanocarriers. ACS Nano 10:6952-6962.