Jayanti Pande

Associate Professor
Chemistry
University at Albany
United States of America

Professor Ophthalmology
Biography

Associate Professor of Chemistry Jayanti Pande's research interests include determining the molecular mechanisms by which genetic mutations and aging alter the proteins in the human eye and lead to eye diseases such as cataracts, glaucoma and macular degeneration. Using a number of biophysical and biochemical methods, her team investigates how soluble proteins and other molecules form insoluble materials that impede normal function and lead to pathology. Their goal is to providing findings that to lead to the development of novel therapeutic strategies.

Research Intrest

Our goal is to determine the molecular mechanisms by which genetic mutations and aging alter the proteins in the human eye and lead to eye diseases such as cataract, glaucoma and macular degeneration. Using a number of biophysical and biochemical methods we investigate how soluble proteins and other molecules form insoluble materials that impede normal function and lead to pathology. We expect our findings to lead to the development of novel therapeutic strategies.

List of Publications
3. Banerjee, P. R., Pande, A., Patrosz, J., Thurston, G. and Pande, J. (2010) Cataract-associated mutant E107A of human gammaD-crystallin shows increased attraction to alpha-crystallin and enhanced light scattering. Proc. Natl. Acad. Sci. U.S.A., 50, 3279-3281.(Cover article, Epub. December 20, 2010),
2. Ghosh KS, Pande A, Pande J. (2011) Binding of γ-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone α-crystallin. Biochemistry. 50, 3279-81. (http://pubs.acs.org/doi/abs/10.1021/bi200091q)
1. Banerjee, P. R., Puttamadappa, S. S., Pande, A., Shekhtman, A. and Pande, J. (2011) Increased Hydrophobicity and Decreased Backbone Flexibility Explain the Lower Solubility of a Cataract-Linked Mutant of γD-Crystallin. J. Mol. Biol. 412,647-659. (http://www.sciencedirect.com/science/article/pii/S0022283611008369)