Harihara Baskaran

Professor
Chemical Engineering
Case Western Reserve University
United States of America

Biography

Education: B.Tech. Chemical Engineering, Anna University (India), 1990 Ph. D. Chemical Engineering, Pennsylvania State University, 1997

Research Intrest

Microvascular Tissue Engineering: Tissue engineering has the potential to revolutionize healthcare. A significant challenge in tissue engineering is to overcome substrate mass transfer limitations, which if ignored can result in a product that will not function adequately. The main goal of this research is to design and build microvascular flow analogs that can be used to overcome nutrient limitations in tissue-engineered products. Cell Transport: Cell transport is important in several physiological and pathological processes such as inflammation, embryogenesis, cancer metastasis and wound healing. Several mechanisms of cell transport have been identified: passive transport through random diffusion and active transport via convection and mechanisms such as chemotaxis, chemokinesis, and haptotaxis. The main goal of this research is to understand various mechanisms of cell transport and to modulate the growth of cell monolayers.

List of Publications
Janakiraman V, Mathur K, Baskaran H. Optimal planar flow network designs for tissue engineered constructs with built-in vasculature. Ann Biomed Eng. 2007 Mar;35(3):337-47. Epub 2007 Jan 3. PubMed PMID: 17203399; PubMed Central PMCID: PMC2613654.
Janakiraman V, Sastry S, Kadambi JR, Baskaran H. Experimental investigation and computational modeling of hydrodynamics in bifurcating microchannels. Biomed Microdevices. 2008 Jun;10(3):355-65. PubMed PMID: 18175219; PubMed Central PMCID: PMC2580727.
Mazzoccoli JP, Feke DL, Baskaran H, Pintauro PN. Development of multilayered cell-hydrogel composites using an acoustic focusing technique. Biotechnol Prog. 2010 Mar;26(2):600-5. PubMed PMID: 19938043; PubMed Central PMCID: PMC2854877.
Breckenridge MT, Egelhoff TT, Baskaran H. A microfluidic imaging chamber for the direct observation of chemotactic transmigration. Biomed Microdevices. 2010 Jun;12(3):543-53. PubMed PMID: 20309736; PubMed Central PMCID: PMC2886973.
Liang WH, Kienitz BL, Penick KJ, Welter JF, Zawodzinski TA, Baskaran H. Concentrated collagen-chondroitin sulfate scaffolds for tissue engineering applications. J Biomed Mater Res A. 2010 Sep 15;94(4):1050-60. PubMed PMID: 20694972; PubMed Central PMCID: PMC2922023.