Associate Professor
Biological Sciences
Louisiana State University
United States of America
Dr. Gregg S. Pettis is currently working as a Associate Professor in the Department of Department of Biological Sciences, Louisiana State University , USA. His research interests includes Gram-negative bacterial genus Vibrio, Gram-positive genus Streptomyces,Phase variation,pathogenesis and conjugation,effective plant pathogens. He is serving as an editorial member and reviewer of several international reputed journals. Dr. Gregg S. Pettis is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Gram-negative bacterial genus Vibrio, Gram-positive genus Streptomyces,Phase variation,pathogenesis and conjugation,effective plant pathogens.
Our lab has research concerning the Gram-negative bacterial genus Vibrio and the Gram-positive genus Streptomyces. The human pathogen Vibrio vulnificus is a contaminant of oysters and other raw shellfish. Phase variation of V. vulnificus occurs among virulent encapsulated, attenuated unencapsulated, and biofilm-proficient rugose forms. Rugose forms of V. vulnificus may contribute to its persistence in its natural marine environment. We are interested in understanding the mechanisms by which phase variation occurs in V. vulnificus. Recently, we found that environmental calcium promotes phase variation in this species. For Streptomyces species, we are interested in the areas of pathogenesis and conjugation. A few Streptomyces species are effective plant pathogens. Streptomyces ipomoeae causes the destructive sweetpotato disease known as soil rot. We are interested in understanding the mechanisms by which Streptomyces plant pathogens including S. ipomoeae cause disease. Specific problems include identifying the genetic determinants of pathogenicity and studying their regulation as well as understanding how pathogenicity continues to evolve in these bacteria. The mechanism by which mycelial Actinobacteria such as Streptomyces species undergo conjugation is unique. Streptomycetes are known to transfer circular plasmids by a novel double-stranded mechanism that involves very few plasmid loci. A particularly interesting aspect of conjugation in these bacteria is that involves both circular and linear plasmids, either of which can also mobilize the Streptomyces chromosome, whose natural configuration is also linear. We are attempting to elucidate further how conjugation of circular and linear DNA forms occurs in these remarkable organisms.