Dr. David Dorman is a professor of toxicology in the Department of Molecular Biosciences of North Carolina State University. He received his undergraduate training in chemistry from the University of San Diego and his DVM from Colorado State University. He completed a combined PhD and residency program in toxicology at the University of Illinois at Urbana-Champaign. Dr. Dorman's research interests include neurotoxicology, nasal toxicology, pharmacokinetics, and cognition and olfaction in animals. He has chaired or served on numerous National Research Council (NRC) committees. In the past six years he has chaired the NRC Committee on Toxicology, Committee on Endocrine-Related Low Dose Toxicity, Committee on Predictive-Toxicology Approaches for Military Assessments of Acute Exposures, Committee on Design and Evaluation of Safer Chemical Substitutions, and the Committee on Potential Health Risks from Recurrent Lead Exposure to DOD Firing Range Personnel. Dr. Dorman was named a National Associate of the NRC in 2016. He has also served on advisory boards for the US Navy, the National Aeronautics and Space Administration, the US Department of Agriculture, AAALAC International, and is a former member of the National Toxicology Program (NTP) Board of Scientific Counselors. Dr. Dorman is an elected fellow of the Academy of Toxicological Sciences and a fellow of the American Association for the Advancement of Sciences. He is a Diplomate of the American Board of Veterinary Toxicology and the American Board of Toxicology. AFFILIATIONS: National Toxicology Program Board of Scientific Counselors North Carolina Scientific Advisory Board on Toxic Air Pollutants National Resource Council (member of several boards and committees) CERTIFICATIONS: Diplomate of the American Board of Veterinary Toxicology Diplomate of the American Board of Toxicology

TOXICOLOGY: My research and professional interests focus on three broad areas: (a) toxicology; (b) cognition and olfaction; and (c) human risk assessments. The primary objective of my research is to provide a refined understanding of potential toxicity in humans from exposure to chemicals. Our laboratory has used a combination of in vivo, in vitro, and modeling approaches to accomplish this aim. Research interests has included evaluation of the role that the olfactory system plays in transporting chemicals from the olfactory epithelium directly to the olfactory bulb and other brain structures (‘nose-to-brain’ transport), examining the effect of chemicals on neonates and other potentially sensitive subpopulations; examination of chemically-induced effects on behavior and cognitive development; and the application of dosimetry modeling and other pharmacokinetic methods to chemical risk assessment. We have worked with a wide range of chemicals including manganese, tungsten, the organophosphate fenitrothion, di-butyl phthalate, acrolein, acetaldehyde, hydrogen sulfide, amongst others. Our laboratory has branched out to evaluate cognition and olfaction in military working dogs. This effort arose in part from our past work examining the effects of chemicals on nasal structure and function in rodents exposed to a variety of inhaled chemicals. Our work sought to improve selection of dogs for use in bomb detection and evaluate olfactory capabilities, learning, and memory in dogs. We have also examined whether early scent exposure to improve scent detection of ammonium nitrate in rats. External Advisory Service: Member of the North Carolina Scientific Advisory Board on Toxic Air Pollutants Member of the National Academies’ Board on Environmental Studies and Toxicology Teaching: I have primary responsibility for the teaching of the following NCSU courses: VMB 954: Veterinary Toxicology and Poisonous Plants VMB 931: Veterinary Ethics and Animal Welfare VMB 991: What the Nose Knows: Olfaction VMB 991: Special Topics in Toxicology BIO 183H: Introductory Biology: Cellular and Molecular Biology (Honors Undergraduate)