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Experts in Anesthesiology
Matthew H Andersen Yaakov Beilin ALEXANDRU I. CARLAN Peter Larsen Daniel S. Talmor Alan Lisbon Sheila M. Ryan-Barnett MICHAEL T. BAILIN JAMES B. KHOURY Peter J. Panzica MARY KRAFT Vimal K. Akhouri Musa Aner Myles D. Boone Ruma R. Bose Somnath Bose Rajiv R. Doshi Matthias Eikermann Stephanie B. Jones Satya Krishna Ramachandran View MoreAlex S. Evers
Professor
Anesthesiology
Washington University School of Medicine
United States of America
My laboratory focuses on the protein chemistry of GABAA receptors to identify and characterize drug binding sites, sequence variants and post-translational modifications as well as to define the protein complexes in which GABAA receptors reside in vivo. A variety of biochemical and molecular biological approaches are applied to these problems, with particular emphasis on high-resolution mass spectrometry. The lab has a longstanding interest in identifying the sites to which anesthetics bind to produce their effects. We have focused on anesthetic neurosteroids, using neurosteroid analogue photolabeling reagents to covalently label protein binding sites and identifying the sites of incorporation using protein mass spectrometry.
Anesthetics, photolabeling, mass spectrometry, proteomics; Molecular mechanisms; anesthetic action; Proteomics of GABAA receptors.