Dr. Raymond Stephen Roginski, is working as an Assistant Professor of Department of Anesthesiology & Critical Care at The University of Pennsylvania Health System. He is also working as Staff Anesthesiologist, Philadelphia VA Medical Center. He received his MD from Albert Einstein College of Medicine, 1985 and PhD from Sue Golding Graduate Division, Albert Einstein College of Medicine of Yeshiva University, 1985. His research interests include: Research on NMDA receptors and GRINL1A interactions has really come to fruition over the past three years. My lab and others around the world have found disease-related roles of GRINL1A (now known by the gene symbol GCOM1) and GRINL1B/GCOM2 genes and proteins, e.g., the Gdown1 protein has been identified as 13th RNA polymerase II subunit; Gup1 is a.k.a. Myozap, a component of the cardiac muscle intercalated disk with a role in a form of cardiomyopathy; the GRINL1B gene was shown to be mutated in acute myeloid leukemia and many other reports such that the total bibliography now exceeds 20 peer reviewed articles. Links to many neuro-psychiatric diseases have been discovered as a result of my lab's yeast two-hybrid (Y2H) screens that revealed 27 new genes that interact with the C- and N-terminal segments of the GRINL1A Gcom1 protein. Therefore, the Y2H studies have firmly connected GCOM1 to glutamatergic neurotransmission and transcription (see publications in Molecular Cell, January 2012). Collaborations continue and are flourishing, especially: Jay Yang (U of Wisconsin) and Patricia Soteropoulos (Bioinformatics at UMDNJ-Rutgers in New Jersey).

Research on NMDA receptors and GRINL1A interactions has really come to fruition over the past three years. My lab and others around the world have found disease-related roles of GRINL1A (now known by the gene symbol GCOM1) and GRINL1B/GCOM2 genes and proteins, e.g., the Gdown1 protein has been identified as 13th RNA polymerase II subunit; Gup1 is a.k.a. Myozap, a component of the cardiac muscle intercalated disk with a role in a form of cardiomyopathy; the GRINL1B gene was shown to be mutated in acute myeloid leukemia and many other reports such that the total bibliography now exceeds 20 peer reviewed articles. Links to many neuro-psychiatric diseases have been discovered as a result of my lab's yeast two-hybrid (Y2H) screens that revealed 27 new genes that interact with the C- and N-terminal segments of the GRINL1A Gcom1 protein. Therefore, the Y2H studies have firmly connected GCOM1 to glutamatergic neurotransmission and transcription (see publications in Molecular Cell, January 2012). Collaborations continue and are flourishing, especially: Jay Yang (U of Wisconsin) and Patricia Soteropoulos (Bioinformatics at UMDNJ-Rutgers in New Jersey).