Dr. Grace Chappell is a Scientist III with ToxStrategies and is based in Austin, Texas. Dr. Chappell has experience in investigating and assessing the underlying molecular mechanisms of carcinogenesis associated with exposure to chemicals commonly found in the environment and/or occupational settings. She received her MSPH and Ph.D. in Environmental Sciences and Engineering from UNC-Chapel Hill by completing research on epigenetic mechanisms (e.g., DNA methylation, chromatin modifications, and microRNA expression) involved in chemical-induced carcinogenesis. To date, her projects have largely focused on epigenetic alterations that appear to be pertinent in tumorigenic processes in organisms exposed to DNA-damaging chemicals.

Dr. Chappell is skilled in computational methods (e.g., quantification of differential signals across many endpoints, identification of functional relevance of genetic/epigenetic signatures) and tools (e.g., R, GSEA, BLAST) for analyzing large “-omics” data sets and developing strategies for data visualization.