Dr. Lok graduated from University of Hong Kong Medical School. She completed her medicine training at Queen Mary Hospital and hepatology training in London under Dame Sheila Sherlock.  She was a faculty at the University of Hong Kong until she moved to the United States in 1992. Dr. Lok joined the University of Michigan in 1995 as Director of the Hepatology Program. She became Associate Chair for Clinical Research in the Department of Internal Medicine in 2008 and Assistant Dean for Clinical Research in 2016. 

Dr. Lok received many awards throughout her career including the Distinguished Scientist Award from the Hepatitis B Foundation and the Distinguished Women Scientist Award from the American Gastroenterological Association (AGA) in 2008, the Distinguished Service Award from the AASLD in 2011, the Distinguished Scientific Achievement Award from the American Liver Foundation in 2015, the William Beaumont Prize in Gastroenterology from the AGA in 2016, a Gold Medal Award from the Canadian Association for the Study of the Liver and an Hon DSc from the University of Hong Kong in 2017.