Find Experts

Experts in Gastroenterology
CHAN Ka Leung, Francis Zhenning Wang Gerald B. Downes Laura I. Francis Andrew J. Bain Mark T. DeMeo Thomas A. Abrams Jad Z. Bou-Abdallah Ladan Fazlollahi DAVID J. DESILETS Paula Burkard Andrew H. Talal Amanpal Singh Michael Albertson Tony CHUNG Kwok Hung Abdul Rashid Khan NG Kwok Wai, Enders WU Che Yuen, Justin Saleh Ali Alqahtani Ramon E. Rivera View More
Urs Steinbrecher

Professor
Division of Gastroenterology
Jack Bell Research Centre
Canada

Academician Gastroenterology
Biography

Dr. Steinbrecher is a Professor, Division of Gastroenterology, UBC.

Research Intrest

Activation of Macrophage Signal Transduction Pathways. My laboratory is interested in the pathogenesis of atherosclerosis, particularly the role of macrophages and their interaction with oxidized LDL. Recent studies have focused on activation of the PI3-kinase/PKB pathway by oxidized LDL. This was shown to activate NFkB, and modulate Bcl-2 family proteins in a manner that prevents apoptosis. In addition, there is crosstalk with sphingolipid signal transduction in that oxidized LDL prevents activation of acid sphingomyelinase, thereby reducing levels its pro-apoptotic product, ceramide.

List of Publications
An unusual cause of colonic swelling. Hereditary angioedema. Wong JC, Steinbrecher UP. Gastroenterology. 2013 Sep;145(3):e11-2. doi: 10.1053/j.gastro.2013.05.054. Epub 2013 Jul 26. No abstract available. PMID: 23896371
Response to endoscopic therapy for biliary anastomotic strictures in deceased versus living donor liver transplantation. Chan CH, Donnellan F, Byrne MF, Coss A, Haque M, Wiesenger H, Scudamore CH, Steinbrecher UP, Weiss AA, Yoshida EM. Hepatobiliary Pancreat Dis Int. 2013 Oct;12(5):488-93. PMID: 24103278
Regulation of ceramide generation during macrophage apoptosis by ASMase and de novo synthesis. Wang SW, Hojabrpour P, Zhang P, Kolesnick RN, Steinbrecher UP, Gómez-Muñoz A, Duronio V. Biochim Biophys Acta. 2015 Nov;1851(11):1482-9. doi: 10.1016/j.bbalip.2015.08.002. Epub 2015 Aug 4. PMID: 26253821
Experts in Canada
Hugh Elton Felix Racine Laure Dubreuil Rodney Fitzsimons Helen Haines Sharon Hepburn Gyles Iannone Anne Keenleyside Paul Manning Anne Meneley Peter Andreas Holly Bates Dr. Dean Greenwood Limin Chen Brian Martin WALLACE CLEMENT SUSAN JAMESON RICHARD MANN MICHAEL BRKLACICH MARIANNE KEYES Linda J. Wykes Luis B. Agellon Paula Alphonse Vern Peters John R. Wood View More