Joseph Lau

Associate Professor
Department of Immunology
Ross University School of Veterinary Medicine
United States of America

Academician Oncology
Biography

Joseph Lau, PhD was working as Distinguished Member in the Department of Molecular and Cellular Biology at Roswell Park Cancer Institute. The central thrusts of the research program are: 1) to elucidate the functional contribution of sialic acid epitopes in normal and malignant processes, and 2) to elucidate the molecular pathways that regulate the attachment of sialic acids. The current main, on-going project is to examine the contribution of the sialyltransferase ST6Gal-I in innate immune responses such as inflammation. There are a number of corollary projects: a) to examine the interaction between sialyltransferases and how this interaction influences the final outcome of sialyl-glycan structures; b) to assess the biologic role of sialyl epitopes and cognate sialyltransferases in development of immune functions; c) To assess the influence of sialic acids on tumor cell surfaces in anti-tumor immunity.

Research Intrest

to examine the contribution of the sialyltransferase ST6Gal-I in innate immune responses such as inflammation.

List of Publications
Jones MB, Nasirikenari M, Feng L, Migliore MT, Lau JTY, et al. (2010) Role for hepatic and circulatory ST6Gal-1 sialyltransferase in regulating myelopoiesis. Journal of biological chemistry 285: 25009-25017
Nasirikenari M, Chandrasekaran EV, Matta KL, Segal BH, Lau JTY, et al. (2010) Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. Journal of leukocyte biology 87: 457-466
Marathe DD, Buffone Jr A, Chandrasekaran EV, Xue J, Lau JTY, et al. (2010) Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins. Blood 115:1303-1312