He was born in Speyer. His father, a Lutheran minister, died while he was a child, leaving a widow and three children. At the age of thirteen Becher found himself responsible not only for his own support but also for that of his mother and brothers. He learned and practiced several small handicrafts, and devoting his nights to study of the most miscellaneous description and earned a pittance by teaching. In 1654, at the age of nineteen, he published the Discurs von der Großmächtigen Philosophischen Universal-Artzney / von den Philosophis genannt Lapis Philosophorum Trismegistus (discours about the allmighty philosophical and universal medicine by the philosopher called Lapis Philosophorum Trismegistus) under the pseudonym 'Solinus Salzthal of Regiomontus.

In 1678, he crossed to England. He travelled to Scotland where he visited the mines at the request of Prince Rupert. He afterwards went for the same purpose to Cornwall, where he spent a year. At the beginning of 1680, he presented a paper to the Royal Society in which he attempted to deprive Huygens of the honour of applying the pendulum to the measurement of time. In 1682, he returned to London, where he wrote the Chymischer Glücks-Hafen, Oder Grosse Chymische Concordantz Und Collection, Von funffzehen hundert Chymischen Processen and died in October of the same year.