Danuta Kozbor

Associate Professor
Department of Immunology
Roswell Park Cancer Institute
United States of America

Academician Oncology
Biography

Dr. Danuta Kozbor joined the staff of the Department of Immunology at Roswell Park Cancer Institute (RPCI) in 2002, as Associate Professor of Immunology and Microbiology. She completed her training as a Postdoctoral Fellow of the National Cancer Institute of Canada at the Wistar Institute in Philadelphia, PA, in 1986.Previously, Dr. Kozbor held a faculty position at Thomas Jefferson University in Philadelphia, PA, the Center for Neurovirology and Cancer Biology at Temple University, Philadelphia, PA. She was also a visiting professor at Kumamoto University, Japan.Dr. Kozbor served as a member of the editorial board of Clinical and Diagnostic Laboratory Immunology and NIAD/NIH study sections on the HIV Vaccine Design and Development Teams for Prevention and Treatment.

Research Intrest

to elucidate molecular and cellular mechanisms of antitumor activities of immuno-oncolytic viral vectors against metastatic tumors. We design novel approaches to enhance the antitumor efficacy of oncolytic virotherapy by expressing therapeutic genes such as the CXCR4 antagonist, augmenting spread of the virus within tumors, and designing novel therapeutic approaches by combining agents with both cytotoxic and immunogenic effects on tumor cells.

List of Publications
Gil M, Bieniasz M, Seshadri M, Fisher D, Kozbor D, et al. (2011) Photodynamic Therapy Augments the Activity of Oncolytic Vaccinia Virus against Primary and Metastatic Tumors in Mice. British Journal of Cancer 105: 1512-1521
Gil M, Bieniasz M, Wierzbicki A, Bambach B, Kozbor D et al. (2009) Targeting a Mimotope Vaccine to Activating Fc gamma Receptors Empower Dendritic Cells to Prime Specific CD8+ T Cell Responses in Tumor-bearing Mice. J. Immunology 183: 6808-18
Wierzbicki A, Gil M, Ciesielski M, Fenstermaker R, Kozbor D, et al. (2008) Immunization with a Mimotope of GD2 ganglioside Induces CD8+ T Cells that Recognize Cell Adhesion Molecules on Tumor Cells. J. Immunology 181: 6644-6653